Bone formation with alloplastic graft substitutes in critical-sized rat calvarial defects
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KMID : 0353320110350020103
Abstract
Purpose: The purpose of this study was to evaluate whether the level of bone formation differed according to the ratio of the hydroxyapatite (HA) and beta-tricalcium phosphate (β-TCP) components.
Materials and Methods: In the cranial area of 60 rats, bone grafts were performed using four bone graft materials with different ratios of HA/β-TCP: (1) unfilled defect, (2) HA (100%), (3) HA (70%)/β-TCP (30%), (4) HA (30%)/β-TCP (70%), and (5) β-TCP (100%). The rats were sacrificed after 4 weeks or 8 weeks, and the bone formation area was evaluated under a light microscope.
Results: In the 4-week groups, the bone formation area in the rats grafted with β-TCP (100%) was 0.75±0.21㎟, and slightly larger bone formation areas were observed than in other groups; nonetheless, these values were not statistically significant in comparison with the other groups. Similarly, significant differences were not shown among any other groups. In the 8-week groups, in the rats grafted with HA (100%) and HA (30%)/β-TCP (70%), bone formation was observed to be 2.60±1.03㎟ and 2.56±0.93㎟, respectively. Thus, more abundant bone formation was observed in these two groups than in the other three groups, and this difference was statistically significant.
Conclusion: Based on the results, the amount of new bone formation is greatest when bone grafts are performed using the graft materials HA 100% or HA (30%)/β-TCP (70%); thus, good bone formation outcomes are expected when using these materials in humans.
키워드
Bone graft; Allogenic; Hydroxyapatite; Beta-tricalcium phosphate
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